Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetSHP1/2 PTPase

Cell permeable: yes

Target IC₅₀: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively

General description

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC₅₀ = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chen, L., et al. 2006. Mol. Pharmacol.70, 562.

Packaging

Packaged under inert gas

50 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)